NBDE Part II Pharmacology MCQ With Answer Key

Question 11: Which of the following is the right statement?

A. Microsomal oxidation always results in inactivation of a compound.

B. Microsomal oxidation results in an increase of ionization and water solubility of a drug.

C. Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated.

D. Microsomal oxidation results in a decrease of compound toxicity.

Answer & Explanation Answer: [B]

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Question 12: Metabolic transformation (phase 1) is defined as:

A. Acetylation and methylation of substances

B. Transformation of substances due to oxidation, reduction or hydrolysis

C. Binding to plasma proteins

D. Glucuronide formation

Answer & Explanation Answer: [B]

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Question 13: Which process takes place in second phase of biotransformation?

A. Acetylation

B. Oxidation

C. Reduction

D. Hydrolysis

Answer & Explanation Answer: [A]

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Question 14: Half life (t ½) depends on:

A. Biotransformation

B. Concentration of a drug in plasma

C. Rate of drug elimination

D. All of the above

Answer & Explanation Answer: [D]

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Question 15: Which of the following is the second messenger of G-protein-coupled (metabotropic) receptor:

A. Adenylyl cyclase

B. cAMP

C. Sodium ions

D. Phospholipase C

Answer & Explanation Answer: [B]

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